SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 ( K i =0.33 nM). SB-612111 hydrochloride exhibits selectivity for μ-, κ- and δ-receptors with K i values ofAppearance:SolidIC50& Target:NOP Receptor/ORL1In Vivo:SB-612111 hydrochloride (intravenous injection; 0.6-10 nmol/mouse) antagonize nociceptin-induced thermal hyperalgesia in a dose-dependent manner with an ED 50 of 0.62mg/kg. SB-612111 hydrochloride (intravenous injection; 0.1-5mg/kg) causes a signifBiological Activity:SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 ( K i =0.33 nM). SB-612111 hydrochloride exhibits selectivity for μ-,xa0κ- andxa0δ-receptors with K i value. Specifications and Purity: 99%. Molecular Formula: C24H30Cl3NO. Molecular Weight: 454.86.
- UPC:
- 12352107
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- S658773-10mg
- Product Size:
- 10mg
