InformationSB743921 HCl SB743921 is a kinesin spindle protein (KSP) inhibitor with K i of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.In vitroThe Ki of SB 743921 for human and mouse KSP is 0.1 nM and 0.12 nM, respectively, while the Ki of SB 743921 for other kinesins including MKLP1, Kin2 is more than 70 μM. SB 743921 blocks assembly of a functional mitotic spindle, thereby causing cell cycle arrest in mitosis and subsequent cell death. SB-743921 has improved potency over ispinesib in both biochemical and cellular assays.In vivoSB-743921 is greater efficacy in vivo against P388 leukemia. SB-743921 has significant efficacy in a broad spectrum of tumor models differing from that of taxanes. SB-743921 is shown to have activity against advanced human tumor xenografts Colo205 (complete regressions), MCF-7, SK-MES, H69, OVCAR-3 (complete and partial regressions), and HT-29, MX-1, MDA-MB-231, A2780 (tumor growth delay). SB-743921 doesn/'t cause the neuropathy often associated with the tubulin agents.Cell Datacell lines：Concentrations：~1 μMIncubation Time：24 hoursPowder Purity:≥95%. Specification: 10mM in DMSO Molecular Formula: C31H33N2O3·HCl Molecular Weight: 553.52
- UPC:
- 51342906
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- S408122-1ml
- CAS:
- 940929-33-9
- Product Size:
- 1ml
