SD-208 (C005B-355728)

Catalog No.: C005B-355728
Mfr. No.: S7071-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $431.51

List Price: $479.45

Application SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells. 2 Biochem/physiol Actions SD-208 is TGF-β:R I kinase inhibitor with IC 50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5)

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Description
Specifications

Application

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.²

Biochem/physiol Actions

SD-208 is TGF-βR I kinase inhibitor with IC₅₀ =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.¹

UPC:: 51432700
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: S7071-5MG
CAS:: 627536-09-8

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