General description
A very potent uptake inhibitor highly selective for serotonin (Ki = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.
Biochem/physiol Actions
Primary Target
5-HT uptake transporter
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383.
Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.
Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.
Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51292027
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 5061880001