Siomycin A

Siomycin A, an antibiotic thiazole compound, has been shown to down-regulate the mRNA and protein abundance as well as transcriptional activity of transcription factor forkhead box M1 (FoxM1). Consequentially, it was demonstrated that the downstream target genes of FoxM1, such as CENP-B, Survivin, and Cdc25B were repressed. This compound was also reported to induce potent p53-independent apoptosis in cancer cell lines of different origin. Siomycin A is an inhibitor of FOXM1.ApplicationSiomycin A from Streptomyces sioyaensis yields clear, colorless to faint yellow solution in DMSO at 10 mg/ml.Siomycin A from Streptomyces sioyaensis may be used in cell signaling studies.Siomycin A has been used as a forkhead box protein M1 (FOXM1) inhibitor to study the effect of pharmacological inhibition of FOXM1 on isocitrate dehydrogenases 1 (IDH1) protein levels. Specification: ≥85% Molecular Formula: C71H81N19O18S5 Molecular Weight: 1648.9 PubChem CID: 16130049 Isomeric SMILES: CC=C1C2=NC(CS2)C(=O)NC(C3=NC(=CS3)C(=O)NC4C(OC(=O)C5=NC6=C(C=CC(C6O)NC(C(=O)NC(=C)C(=O)NC(=C)C(=O)NC(C(=O)NC7(CCC(=NC7C8=CSC4=N8)C9=NC(=CS9)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C2=NC(=CS2)C(=O)NC(C(=O)N1)C(C)O)C)C(C)C)C(=C5)C(C)O)C)C(C)(C(C)O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S329546-SCI_9c9ac9e7115c20ed95a9d94b231bf3bc.pdf