General description
A cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50 = 3.5 µM) with little activity against SIRT1/3 (IC50 >50 µM). Prevents cellular α-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue α-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Preparation Note
Slight warming may be required for complete solubilization.
Other Notes
Outerio, T.F., et al. 2007. Science317, 516.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 12352200
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 566324-5MG