SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC 50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN.Appearance:SolidIC50& Target:CereblonIn Vitro:SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC 50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In Vivo:SJF620 hydrochloride has a super pharmacokinetic profile in mice (1mg/kg; i.v.) with the half life (t 1/2 ) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802. MCE has not independently confirmed the accuracy of theBiological Activity:SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC 50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN. Molecular Formula: C41H45ClN8O7 Molecular Weight: 797.3
- UPC:
- 51343405
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- S659469-10mg
- Product Size:
- 10mg
