SKF 83959 HYDROBROMIDE

Catalog No.: C005B-372257
Mfr. No.: S2816-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $564.74

List Price: $627.49

Application SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα: in mice. Biochem/physiol Actions SKF-83959 is an atypical agonist of D 1 dopamine receptor and an allosteric

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Description
Specifications

Application

SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice.

Biochem/physiol Actions

SKF-83959 is an atypical agonist of D₁ dopamine receptor and an allosteric modulator of σ-1 receptor on in brain and liver tissues. It has neuroprotective and anti-parkinsonian effects through selective activation of phosphoinositol-linked D₁ receptor and promotes migration of cultures astrocytes by ERK1/2 activation. In in vitro studies SKF-83959 exhibits antagonist activity against dopamine D₁ receptors coupled to adenylyl cyclase.

D₁ dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo.

UPC:: 51144008
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: S2816-5MG
CAS:: 80751-85-5

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