Product description：SKLB-23bb is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively.InformationSKLB-23bb is an orally bioavailableHDAC6-selectiveinhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.TargetsHDAC6 (Cell-based assay) <100 nMIn vitroSKLB-23bb shows cytotoxic effects against a panel of solid and hematologic tumor cell lines at the low submicromolar level. In contrast to the reported HDAC6-selective inhibitors, SKLB-23bb is more efficient against solid tumor cells. SKLB-23bb selectively inhibits cellular HDAC6, but the antitumor activity of SKLB-23bb is independent of HDAC6. SKLB-23bb could bind to the colchicine site in β-tubulin and act as a microtubule polymerization inhibitor. It blocks tumor cell cycle at G2-M phase and triggers cellular apoptosis.In vivoIn solid tumor xenografts, oral administration of SKLB-23bb efficiently inhibits tumor growth. SKLB-23bb has good pharmacokinetic profiles and is orally bioavailable.Cell Research(from reference)Cell lines：HCT116 and A2780S cells Concentrations：200 nM Incubation Time：3, 6, 12 and 24 h. Specification: 0.97 Molecular Formula: C21H24N4O4 Molecular Weight: 396.44 PubChem CID: 122550211 Isomeric SMILES: CC1=NC2=CC=CC=C2C(=N1)N(C)C3=CC(=C(C=C3)OC)OCCCC(=O)NO
- UPC:
- 51111802
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- S414149-25mg
- CAS:
- 1815580-06-3
- Product Size:
- 25mg
