SKM 4-45-1 (C09-1041-872)

The cellular trafficking of arachidonoyl ethanolamide (anandamide; AEA) by neurons is dominated by hydrolysis and/or transport by fatty acyl amide hydrolase (FAAH) within the neurons.1 SKM 4-45-1 is a labeled analog of AEA that is non-fluorescent when outside the cell. Upon transport into the cell interior, it is cleaved by esterases to give a bright fluorescence at 530 nm. SKM 4-45-1 uptake into C6 glioma cells is inhibited by AEA and its analogs, and conversely SKM 4-45-1 inhibits the uptake of tritiated AEA, indicating that they compete for the AEA transporter. Specification: A solution in methyl acetate Molecular Formula: C47H52N2O10 Molecular Weight: 804.92 PubChem CID: 101044770 Isomeric SMILES: CCCCC/C=C/C/C=C/C/C=C/C/C=C/CCCC(=O)NCCOC(=O)NC1=CC2=C(C=C1)C3(C4=C(C=C(C=C4)OC(=O)C)OC5=C3C=CC(=C5)OC(=O)C)OC2=O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S351086-SCI_3c7e9a373eba0c07a6ddf6b67dcd46a3.pdf