SL327 MIXTURE OF E & Z ISOMERS (C005B-368001)

Catalog No.: C005B-368001
Mfr. No.: S4069-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $1,208.73

List Price: $1,343.04

Application SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase :(MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC). SL327 was used to study the role of MAPK signaling in interictal spiking

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Description
Specifications

Application

SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).

SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.

Biochem/physiol Actions

SL327 is a selective MEK1/2inhibitor (IC₅₀ values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

UPC:: 51142040
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: S4069-25MG
CAS:: 305350-87-2

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