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smac/diablo (c15-1301-384)

Smac/DIABLO (C15-1301-384)

Catalog No.
C15-1301-384
Manufacturer No.
23-057
Manufacturer Name
Sigma-Aldrich
Quantity
10
Unit of Measure
UG
Price: $1,138.78
List Price: $1,265.31

Smac/DIABLO is a mitochondrial protein that is proteolytically processed and released during apoptosis along with cytochrome c and other pro-apoptotic factors. Once in the cytosol, Smac/DIABLO binds to inhibitors of apoptosis (IAP) proteins and

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General description

Smac/DIABLO is a mitochondrial protein that is proteolytically processed and released during apoptosis along with cytochrome c and other pro-apoptotic factors. Once in the cytosol, Smac/DIABLO binds to inhibitors of apoptosis (IAP) proteins and disrupts the ability of the IAPs to inhibit caspases 3, 7, and 9 thereby promoting apoptosis. Along with several other pro-apoptotic proteins, Smac/DIABLO has been shown to be a substrate for the ubiquitin ligase XIAP.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

biological source: human. Quality Level: 100. form: liquid. manufacturer/tradename: Upstate®. . technique(s): activity assay: suitable. NCBI accession no.: NM_019887. Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H317. Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364. Hazard Classifications: Skin Sens. 1. Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
UPC:
51343006
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
23-057


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