General description
The TGF-β signalling cascade regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, adhesion and migration. It plays a fundamental role in a number of different physiological and pathological processes, such as embryonic development, adult homoeostasis, tumourigenesis and tissue fibrogenesis. Smad7 has been identified as a key negative regulator of TGF-β signalling, antagonising it through multiple mechanisms in both the cytoplasm and in the nucleus. Altered expression of Smad7 is often associated with human diseases, such as cancer, tissue fibrosis and inflammatory diseases.
Application
Ubiquitination Cascade Comoponent: Substrate
Physical form
Purified using immobilized metal affinity chromatography.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source: human. Quality Level: 100. form: liquid. manufacturer/tradename: Upstate®. . technique(s): activity assay: suitable. NCBI accession no.: NM_005904. Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H317. Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364. Hazard Classifications: Skin Sens. 1. Storage Class Code: 10 - Combustible liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51152013
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 23-039
