General description
Interleukin-22 (IL-22), also known as IL-10-related T-cell-derived inducible factor (IL-TIF), is a member of the IL-10 cytokine family. Mainly produced by activated T-cells and natural killer cells, IL-22 binds to a receptor complex with two components, CRF2-4 and IL-22R. The signaling cascade is said to up-regulate pro-inflammatory cytokines and antimicrobial peptides, and induce production of acute-phase reactants in liver and hepatoma cells. The biological function of IL-22 is associated with many inflammatory disorders, including Crohn′s disease, inflammatory bowel disease, psoriasis, rheumatoid arthritis and ulcerative colitis.Thus, IL-22 remains an attractive therapeutic target because of its pro-inflammatory properties.
The SMC® IL-22 Immunoassay Kit contains all reagents required to perform the assay. This assay takes advantage of a standard immunoassay workflow configured in a standard plate format. Assay protocols are similar to existing sandwich ELISA methods with two key differences: 1) Elution buffer disrupts the sandwich, separating the labeled detection antibody for quantification. 2) The SMC® immunoassay system detects analytes using Single Molecule Counting (SMC®) technology.
Application
Research Category
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors
The sensitivity of Single Molecule Counting (SMC®) gives the SMC® Human IL-22 Immunoassay Kit unparalleled performance in the quantification of IL-22 in human EDTA plasma.
Used to detect/quantify:IL-22
Components
IL-22 Coated Beads
Standard Diluent
IL-22 Detection Antibody
Assay Buffer
IL-22 Standard
SMC® Human IL-22 Immunoassay Kit Instructions
10X Wash Buffer
Elution Buffer B
Buffer D
Analysis Note
Low-end CV% Average: 2 - 20%|Low-end CV% Range: 11%
Legal Information
SMC is a registered trademark of Singulex
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
Shipping Information:
Dry Ice Surcharge & Ice Pack Shipments: $40
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- UPC:
- 41116127
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 03-0059-01
- Temperature Control Device:
- Yes
