Smoothened Agonist (SAG) HCl is a cell-permeableSmoothened(Smo) agonist withEC50of 3 nM in Shh-LIGHT2 cells.TargetsSmoothened (mouse cultured cell assay) 3 nM(EC50)In vitroSAG regulates Smo activity by binding directly to the Smo heptahelical bundle. SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells.In vivoIn the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities.
Specification: ≥99%
Molecular Formula: C28H29Cl2N3OS
Molecular Weight: 526.52
PubChem CID: 121540649
- UPC:
- 51142432
- Condition:
- New
- Availability:
- 1 day
- Weight:
- 0.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- S413830-2mg
- CAS:
- 2095432-58-7
- Product Size:
- 2mg
