General description
A peptidyl toxin present in the venom of African tarantula, Hysterocrates gigas that acts as a high affinity, reversible blocker of Cav2.3 (α1E, R-type) channels (IC50 = 15-30 nM). The inhibition appears to be voltage-dependent. At lower concentrations it is also shown to block native R-type Ca2+ current in rat neurohypophyseal nerve terminals, however, these effects are not observed at higher concentrations. Does not affect Na+ or K+ currents in several cultured cell types (~ 500 nM).
Biochem/physiol Actions
Primary Target
Cav2.3 channels
Warning
Toxicity: Standard Handling (A)
Sequence
GVDKAGCRYMFGGCSVNDDCCPRLGCHSLF→SYCAWDLTFSD (difulfid bond: 7-21, 14-26, 20-33)
Reconstitution
Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Abitbol, K. et al. 2012. J. Physiol.590, 2977.
Newcomb, R., et al., 1998. Biochemistry.37, 15353.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51442717
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 5085120001
