Sodium cholate hydrate (C09-1031-279)

Cholate is a primary bile acid produced from cholesterol in the liver. It is an anionic detergent synthesized from cholesterol in the presence of sterol 12α-hydroxylase (CYP8B1). Application：Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes.Sodium cholate hydrate has been used:as a bile acid to induce bile acid-responsive (BEAR) transcription system,as a component of Campylobacter defined broth (CDB) to test its effect on stress response in Campylobacter jejuni{52to test its sensitivity towards the bile acid sensor;. Specification: for cell culture,≥99.0% MDL Number: MFCD00064138 Molecular Formula: C24H39NaO5 · xH2O Molecular Weight: 430.55 (anhydrous basis) EC Number: MFCD00150749 PubChem CID: 23679061 Isomeric SMILES: C[C@H](CCC(=O)[O-])[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C.O.[Na+] Beilstein Registry Number: 3582354 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S104206-SCI_e233d125d1b370895703598e84fca994.pdf