SP 600125 (C005B-363043)

Catalog No.: C005B-363043
Mfr. No.: S5567-10MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 10
UOM: MG

Price: $307.43

List Price: $341.59

Application C2C12 myoblasts were treated with SP600125 to test the stimulation of myogenesis. 11 It was used to treat HepG2 cells to test the effects on oxysterol-induced necrosis.

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Description
Specifications

Application

C2C12 myoblasts were treated with SP600125 to test the stimulation of myogenesis.¹¹ It was used to treat HepG2 cells to test the effects on oxysterol-induced necrosis.¹²

Biochem/physiol Actions

SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.^8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.¹⁰

A novel and selective inhibitor of c-Jun N-terminal kinase (JNK)

UPC:: 51112000
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: S5567-10MG
CAS:: 129-56-6

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