Biochem/physiol Actions SPA70 is a cell penetrant, potent and highly selective human pregnane X receptor (hPXR) antagonist that inhibits hPXR in humanized mouse models. It inhibits hPXR-mediated drug metabolism in in primary human hepatocytes and
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SPA70 is a cell penetrant, potent and highly selective human pregnane X receptor (hPXR) antagonist that inhibits hPXR in humanized mouse models. It inhibits hPXR-mediated drug metabolism in in primary human hepatocytes and in mouse models.
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