General description
A broad spectrum aminoglycoside antibiotic that contains two glucose moieties. Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure. A resistance gene (aph) which encodes a spectinomycin has been cloned from Legionella pneumophila (disease agent for Legionnaire’s disease) kinase and expressed in E. coli. Potency: ≥500 µg/mg.
A broad spectrum aminoglycoside antibiotic that contains two glucose moieties. Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure. A resistance gene (aph) which encodes a spectinomycin has been cloned from Legionella pneumophila (disease agent for Legionnaire′s disease) kinase and expressed in E. coli.
Biochem/physiol Actions
Primary Target
Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure
Warning
Toxicity: Standard Handling (A)
Other Notes
Thompson, P.R., et al. 1998. J. Biol. Chem. 273, 14788.
Noah, J., and Wollenzien, P. 1997. Nucleic Acids Symp. Ser. 36, 178.
Suter, T.M., et al. 1997. Antimicrob. Agents Chemother. 41, 1385.
Thom, G., and Prescott, C.D. 1997. Bioorg. Med. Chem. 5, 1081.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51281666
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 567570-10GM
- CAS:
- 22189-32-8
