Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. Formed from spermidine through the addition of aminopropyl group to spermidine by spermine synthase. It is found as a polycation at physiological pH. Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
- UPC:
- 42143207
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazMatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- 215207001
