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sphingosine kinase 1 inhibitor, ski-178 - calbiochem (c15-1305-935)

SPHINGOSINE KINASE 1 INHIBIT 1PC X 10MG (C15-1305-935)

Catalog No.
C15-1305-935
Mfr. No.
567732-10MG
Mfr. Name
Sigma-Aldrich
Qty/UOM
10
UOM
MG
Price: $351.97
List Price: $391.07

A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (K i = 1.33 and >>25

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General description

A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >>25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Hengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett.20, 7498

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 394.42. Empirical Formula: C21H22N4O4. Assay: ≥. 92% (HPLC). Quality Level: 100. form: powder. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, protect from light. color: off-white. solubility: DMSO: 100 . mg/mL. shipped in: ambient. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
UPC:
51111739
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
567732-10MG

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