General description
Cell-permeable adenylate cyclase inhibitor. Blocks PTH-stimulation of adenylate cyclase (IC50 = 200 µM). Reduces PGE2-induced inhibition of O2·– production.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
adenylate cyclase
Product does not compete with ATP.
Reversible: no
Target IC50: 200 µM against adenylate cyclase
Warning
Toxicity: Irritant (B)
Reconstitution
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.
Other Notes
Talpain, E., et al. 1995. Br. J. Pharmacol. 114, 1459.
Tamaoki, J., et al. 1993. Prostaglandins45, 363.
Fabbri, E., et al. 1991. J. Enzyme Inhib.5, 87.
Goldsmith, B.A. and Abrams, T.W. 1991. Proc. Natl. Acad. Sci. USA 88, 9021.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 42272522
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 568500-5MG