SR-318 (C005B-310022)

Catalog No.: C005B-310022
Mfr. No.: SML2839-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $227.41

List Price: $252.67

Biochem/physiol Actions SR-318 is a potent and selective type-II inhibitor that targets p38α:/β: in an inactive DFG-out conformation with good kinome selectivity (p38α:/β: IC 50 = 5/39 nM by radiometric kinase assay). SR-318

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Description
Specifications

Biochem/physiol Actions

SR-318 is a potent and selective type-II inhibitor that targets p38α/β in an inactive DFG-out conformation with good kinome selectivity (p38α/β IC₅₀ = 5/39 nM by radiometric kinase assay). SR-318 selectively inhibits p38α/β by cell-based NanoBRET assay (IC₅₀ = 3.7 nM/p38α, 10 nM/p38β, 0.91 μM/ZAK, ≥3 μM/DDR1, DDR2, KIT, MYLK4, RSK4) and effectively blocks LPS-induced TNF-α release in human whole blood (IC₅₀ = 283 nM). SR-321 is an inactive structural analog and the recommended negative control compound.

UPC:: 51112007
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML2839-5MG
CAS:: 2413286-32-3

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