SR-4370 (C09-1044-036)

InformationSR-4370 is a potent and selective inhibitor of class I HDACs with IC50 of 0.13 µM, 0.58 µM, 0.006 µM, 2.3 µM, 3.7 µM forHDAC 1,HDAC 2,HDAC 3,HDAC 8,HDAC 6, respectively.SR-4370 suppresses AR signaling and in vivo prostate tumor growth.TargetsHDAC3 (Cell-free assay); HDAC1 (Cell-free assay); HDAC2 (Cell-free assay); HDAC8 (Cell-free assay); HDAC6 (Cell-free assay) ;0.006 μM; 0.13 μM; 0.58 μM; 2.3 μM; 3.7 μMIn vitroSR-4370 can induce cell death of the aggressive breast cancer MDAMB-231 cells with IC50 of 12.6 μM..Cell Research(from reference)Cell lines：MDA-MB-231 cells Concentrations：0-100 μM. Specification: 0.99 Molecular Formula: C17H18F2N2O Molecular Weight: 304.33 PubChem CID: 118418385 Isomeric SMILES: CCCCNNC(=O)C1=CC=C(C=C1)C2=C(C(=CC=C2)F)F Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S412770-SCI_b0985e35d7ca3f348c74c87c5b4b4be2.pdf