SU14813 maleate (C09-1170-960)

SU14813 maleate is a multi-targeted receptor tyrosine kinases inhibitor with IC 50 s of 50, 2, 4, 15 nM for VEGFR2 , VEGFR1 , PDGFRβ and KIT .In VitroSU14813 inhibits ligand-dependent and ligand-independent proliferation, migration, and survival of endothelial cells and/or tumor cells expressing these targets. SU14813 inhibits cellular ligand-dependent phosphorylation of VEGFR-2 (transfected NIH 3T3 cells), PDGFR-β (transfected NIH 3T3 cells), KIT (Mo7e cells), and FLT3-internal tandem duplication (FLT3-ITD; MV4;11 cells) as well as FMS/CSF1R (transfected NIH 3T3 cells). SU14813 inhibits VEGFR-2, PDGFR-β, and KIT phosphorylation in porcine aorta endothelial cells overexpressing these targets, with cellular IC 50 values of 5.2, 9.9, and 11.2 nM, respectively. SU14813 inhibits the growth of U-118MG with an IC 50 of 50 to 100 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoSU14813 inhibits VEGFR-2, PDGFR-β, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent fashion. The plasma concentration required for in vivo target inhibition is estimated to be 100 to 200 ng/mL. Used as monotherapy, SU14813 exhibits broad and potent antitumor activity resulting in regression, growth arrest, or substantially reduced growth of various established xenografts derived from human or rat tumor cell lines. Treatment in combination with docetaxel significantly enhances both the inhibition of primary tumor growth and the survival of the tumor-bearing mice compared with administration of either agent alone . MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:VEGFR2 50 nM (IC 50 ) VEGFR1 2 nM (IC 50 ) PDGFRβ 4 nM (IC 50 ) KIT 15 nM (IC 50 ). Specification: 10mM in DMSO Molecular Formula: C27H31FN4O8 Molecular Weight: 558.56