Super-TDU TFA (C09-1044-404)

TargetsYAP/TEAD interactionIn vitroSuper-TDU reduced endogenous interaction between YAP and TEADs. It inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27, but not MKN-45. Moreover, the Super-TDU downregulated expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU significantly inhibited growth of HeLa, MGC-803, HCT116, A549, and MCF-7 cells, but only marginally inhibited growth of Jurkat and Raji cells, indicating a selectivity of the Super-TDU in inhibiting tumor cell growth. Super-TDU may specifically target tumor cells with an elevated YAP/VGLL4 ratio.In vivoSuper-TDU has the potential in treating gastric cancer by directly targeting YAP-TEADs, and importantly, unlike the conventional drug compound 5-FU, its antitumor activity tends to be specific toward tumors with an elevated ratio of YAP to VGLL4.Cell Research(from reference)Cell lines：HCT116 and SW480 cells Concentrations：0-320 ng/ml Incubation Time：72 h. Specifications and Purity: 98%. Molecular Formula: C237H369N65O70S(free base). Molecular Weight: 5280.92(free base).