Tabersonine hydrochloride (C09-1074-247)

InformationTabersonine hydrochloride Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.TargetsAβ(1−42) aggregationIn vitroTabersonine disrupts Aβ(1−42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. It binds to Aβ(1−42) oligomers more strongly than to Aβ(1−42) monomers with Kd values of 69 μM and 535 μM, respectively.In vivoThe biocompatibility and small size essential for permeating the blood−brain barrier make tabersonine a potential therapeutic drug candidate for treating Alzheimer/'s disease (AD).Product Application：(-)-Tabersonine Hydrochloride is the hydrochloride salt of (-)-Tabersonine.(-)-Tabersonine is one of the terpenoid indole alkaloids (TIAs) from Catharanthus roseus. (-)-Tabersonine shows hypotensive activity, anti-tumor activity, hypoglycemic, diuretic activity.Cell Research(from reference)Cell lines：SH-SY5Y cell Concentrations：10 μM Incubation Time：24 h. Specification: 0.98 Molecular Formula: C21H24N2O2.HCl Molecular Weight: 372.89 PubChem CID: 12443187 Isomeric SMILES: CC[C@]12CC(=C3[C@@]4([C@H]1N(CC4)CC=C2)C5=CC=CC=C5N3)C(=O)OC.Cl Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/T413228-SCI_703eb48a4cc870842cd52a91d1c88765.pdf