InformationTAK-063 (Balipodect) is a novel and selectivephosphodiesterase 10A(PDE10A)inhibitor with an IC50 of 0.30 nM.TargetsPDE10A (Cell-free assay) 0.3 nMIn vivoTAK-063 has high brain penetration in mice. Oral administration of TAK-063 to mice elevated striatal cAMP and (cGMP) levels at 0.3 mg/kg and shows potent suppression of phencyclidine (PCP)-induced hyperlocomotion at a minimum effective dose (MED) of 0.3 mg/kg. TAK-063 is currently being evaluated in clinical trials for the treatment of schizophrenia. Specification: 0.98 Molecular Formula: C23H17FN6O2 Molecular Weight: 428.42 PubChem CID: 46848915 Isomeric SMILES: COC1=CN(N=C(C1=O)C2=CC=NN2C3=CC=CC=C3)C4=C(C=C(C=C4)N5C=CC=N5)F Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/T414018-SCI_e99d7a2034c03701a5d69fceaf8e2f59.pdf
- UPC:
- 51332871
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- T414018-10mg
- CAS:
- 1238697-26-1
- Product Size:
- 10mg
- Hazard Statement Codes:
- H302:H315:H319:H335
- Precautionary Statement Codes:
- P261:P305+P351+P338
