Tamm-Horsfall Glycoprotein (C15-1318-341)

General description

Tamm-Horsfall glycoprotein (THGP) also known as uromodulin is abundantly present in mammalian urine. It is highly expressed in the thick ascending limb of the Henle′s loop in the kidney. This protein consists of three epidermal growth factor (EGF) domains and a zona pellucida-like domain. THGP is a member of the glycosylphosphatidylinositol (GPI) protein family and is attached to the cell membrane by a C-terminal GPI- anchor. The THGP gene is located on the human chromosome at 16p12.3.

Application

Tamm-Horsfall Glycoprotein has been used in luciferase activity assay of immortalized proximal tubular cells and human primary proximal tubular epithelial cells. It has also been used as a standard for calibration of uromodulin in urine samples.

Biochem/physiol Actions

Tamm-Horsfall glycoprotein (THGP) may play a role in antibacterial host defense, inflammatory kidney disease, and the urogenital tract. It exhibits protective effects against kidney stone formation by reducing the calcium oxalate precipitation. Mutations in the THGP gene lead to familial juvenile hyperuricemic nephropathy (FJHN), glomerulocystic kidney disease (GCKD), and medullary cystic kidney disease type 2 (MCKD-2).

Physical form

Lyophillized from deionized water containing 0.02% sodium azide.

Storage and Stability

Store +2-8°C for up to 3 months after date of receipt.

DO NOT FREEZE.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: human. Quality Level: 100. Assay: >. 95%. form: solid. manufacturer/tradename: Chemicon^®. . NCBI accession no.: NM_001008389.1, NM_003361.2. UniProt accession no.: P07911. shipped in: wet ice. Gene Information: human ... UMOD(7369). Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.