TCEP-FREE ACID 1GM UN3261

TCEP is a water-soluble, odorless, non-toxic and stable protein reductant. This potent reducing agent is a popular alternative to ß-mercaptoethanol and DTT (dithiothreitol) use for most applications. The reduction potency of TCEP is twice as high as that of DTT, and TCEP is effective in reducing proteins over a wider range of pH conditions, including lower acidic pH ranges (pH 2-11), compared to other reductants. Since TCEP is a charged molecule, it cannot penetrate hydrophobic environments. Therefore, the use of a denaturant, acidic condition (pH 2.8-5) or basic condition (pH 9-11), is recommended for effective reduction. TCEP reduces stable disulfide bonds in less than 5 minutes at room temperature and is compatible with the protein alkylation reactions. Features Chemical Name: tris(2-carboxyethyl)phosphine, HCl Synonym: TCEP, Hydrochloride CAS Number: 51805-45-9 Chemical Formula: C₉H₁₅O₆P•HCl Molecular Weight: 286.65 Form: White crystalline solid Solubility: H₂O (5mg/ml) Applications Reduction of protein and peptide solutions