General description
T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is a 14 kDa product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL). TCL1 protein is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T-cell leukemia and B-cell lymphoma. TCL1 binds to a novel site in the pleckstrin homology (PH) domain, resulting in activation and nuclear translocation of Akt by overexpressed TCL1 which may promote an anti-apoptotic response; this may normally serve to promote growth during development but may lead to malignancy when TCL1 is overexpressed. TCL1 is expressed in differentiated B-cells under both reactive and neoplastic conditions, antigen committed B-cells, and in germinal center B-cells. TCL1 is down-regulated in the latest stage of B-cell differentiation. TCL1 is overexpressed in Burkitt lymphoma, the majority of AIDS-related non-Hodgkin lymphoma-designated immunoblastic plasmacytoid lymphoma, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma. Therefore, the most useful application of anti-TCL1 is the discrimination of B-cell lymphomas from T-cell lymphomas, CD30+ anaplastic large cell lymphomas, multiple myeloma, and marginal zone B-cell lymphoma.
Quality
IVD | IVD | IVD | RUO |
Linkage
TCL1 Positive Control Slides, Product No. 357S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a trademark of Sigma-Aldrich Co. LLC
biological source: mouse. Quality Level: 100, 500. conjugate: unconjugated. antibody form: culture supernatant. antibody product type: primary antibodies. clone: MRQ-7, monoclonal. description: For In Vitro Diagnostic Use in Select Regions (See Chart). form: buffered aqueous solution. species reactivity: human. packaging: vial of 0.1 . mL concentrate (357M-14), vial of 0.5 . mL concentrate (357M-15), bottle of 1.0 . mL predilute (357M-17), vial of 1.0 . mL concentrate (357M-16), bottle of 7.0 . mL predilute (357M-18). manufacturer/tradename: Cell Marque™. . technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500. isotype: IgG. control: B-cell lymphoma, tonsil. shipped in: wet ice. storage temp.: 2-8°C. visualization: cytoplasmic, nuclear. Gene Information: human ... TCL1A(8115).- UPC:
- 12352203
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 357M-16