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tdzd-8 (c09-1073-975)

TDZD-8 (C09-1073-975)

Aladdin

Catalog No.
C09-1073-975
Manufacturer No.
T409003-1ml
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $305.20
List Price: $339.11

InformationTDZD-8 (NP 01139) is a non-ATP competitiveGSK-3βinhibitor withIC50of 2 μM minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.In vitroTDZD-8 acts as a noncompetitive inhibitor of ATP or GS-1 binding. TDZD-8 shows no

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InformationTDZD-8 (NP 01139) is a non-ATP competitiveGSK-3βinhibitor withIC50of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.In vitroTDZD-8 acts as a noncompetitive inhibitor of ATP or GS-1 binding. TDZD-8 shows no inhibition of PKA, PKC, Cdk-1/cyclin B or CK-II in kinase assays. TDZD-8 specifically induces cell death of primary leukemia specimens. TDZD-8 ablates leukemia progenitor and stem cells. TDZD-8 treatment induces oxidative stress. TDZD-8 induces cell death with extremely rapid cell death kinetics showing loss of membrane integrity. TDZD-8 inhibits PKC and FLT3 in primary AML specimens.In vivoCell Datacell lines：Concentrations：Incubation Time：Powder Purity:≥99%. Specifications and Purity: 10mM in DMSO. Molecular Formula: C10H10N2O2S. Molecular Weight: 222.26.
UPC:
12352115
Condition:
New
Availability:
8-12 weeks
Weight:
0.85 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
T409003-1ml
CAS:
327036-89-5
Product Size:
1ml


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