Tetanus Toxin, C-Fragment, Clostridium tetani - Calbiochem (C15-1306-558)

General description

Caution: may contain trace amounts of intact toxin.

The C-terminal binding portion of the chain of tetanus toxin. The intact toxin is known to block neurotransmitter release at inhibitory synapses in cultured spinal cord cells. Shows trans-synaptic retrograde transport in the central nervous system. Caution: may contain trace amounts of intact toxin. Follow the handling procedure described in the information that accompanies the product.

The C-terminal binding portion of the heavy chain of tetanus toxin.

The C-terminal binding portion of the heavy chain of tetanus toxin. Useful for binding studies.

Biochem/physiol Actions

Primary Target
Useful for binding studies

Product does not compete with ATP.

Warning

Toxicity: Highly Toxic (H)

Physical form

Lyophilized from 10 mM sodium phosphate buffer, pH 7.5.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Once an aliquot has been thawed, do not refreeze. Aqueous stock solutions are stable for 7-10 days at 4°C.

Analysis Note

Single major band by SDS-PAGE

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Poulain, B. 1994. Pathol. Biol. 42, 173.
Williamson, L.C., et. al. 1993. Soc. Neurosci. 19, Abstract 770.10.
Evinger, C. and Erichsen, J.T. 1986. Brain Res.380, 383.
Helting, T.B. and Zwisler, O. 1977. J. Biol. Chem.252, 187.
Matsuda, M. and Yoneda, M. 1977. Biochem. Biophys. Res. Commun.77, 268.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Quality Level: 100. form: lyophilized. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze. solubility: sterile distilled water: soluble. shipped in: ambient. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3.