tetranor-PGEM-d6 (C09-1069-990)

tetranor-PGEM-d6 contains six deuterium atoms at the 13, 13', 14, 14', 15, and 15' positions and is intended for use as an internal standard for the quantification of tetranor PGEM by GC- or LC-mass spectrometry. Tetranor PGEM-d6 is the major urinary metabolite of PGE1 and PGE2 and is used as a urinary marker of PGE2 biosynthesis, and to monitor metabolism after infusion or injection of PGE1 as a pharmaceutical. Normal healthy males excrete 16-30 μg of tetranor PGEM over a 24-hour period. Females excrete less by about a factor of three. Following oral administration (4 x 50 mg/24 hours) of the COX inhibitor, indomethacin, urinary levels of tetranor PGEM decrease by 75-98% indicating the almost complete loss of PGE2 biosynthesis. Specification: A solution in methyl acetate Molecular Formula: C16H18O7D6 Molecular Weight: 334.39 PubChem CID: 87094813 Isomeric SMILES: [2H]C([2H])(CC(=O)CC[C@H]1[C@@H](CC(=O)[C@@H]1CCC(=O)O)O)C([2H])([2H])C([2H])([2H])C(=O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/T334329-SCI_c1fa7709dfa816f42c824733059c4009.pdf