Transforming Growth Factor-alpha (TGF-a) , also known as sarcoma growth factor, TGF-type I and ETGF, is a member of the EGF family of cytokines. It is expressed in monocytes, brain cells, keratinocytes and various tumor cells. TGF-a signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells. TGF-a is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. The biological actions of TGF-a and EGF are similar. For instance, TGF-a and EGF bind to the same receptor. When TGF-a binds to EGFR it can initiate multiple cell proliferation events. Recombinant Human TGF-a produced in E. coli cells is a single non-glycosylated polypeptide chain containing 50 amino acids. A fully biologically active molecule, rhTGF-a has a molecular mass of 5.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
- UPC:
- 41122409
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Z03332-50
