Transforming growth factor beta 2 (TGF-ß2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-ß2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-ß isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-ß receptor type II (TßR-II), and a TGF-ß receptor type I (TßR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-ß expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, hematopoietic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system. Recombinant Mouse TGF-ß2 produced by a mammalian expression system is a polypeptide chain containing 112 amino acids. A fully biologically active molecule; rm TGF-ß2 a molecular mass of 12.7 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
- UPC:
- 41122409
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Z03432-10
