Thailanstatin A (C09-1182-655)

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing ( IC 50 =650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC 50 s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC .In VitroThailanstatin A (TST-A) is a potent antiproliferative natural product, can be discovered from Burkholderia thailandensis MSMB43. ?/nThailanstatin A (DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells) exhibits potent antiproliferative activities with GI 50 s in the single nM range (1.11-2.69 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid. Specification: 0.98 Molecular Formula: C28H41NO9 Molecular Weight: 535.63 PubChem CID: 71665768 Isomeric SMILES: C[C@H]1C[C@H]([C@H](O[C@H]1C/C=C(/C)/C=C/[C@@H]2[C@H]([C@@]3(C[C@H](O2)CC(=O)O)CO3)O)C)NC(=O)/C=C/[C@H](C)OC(=O)C