Application
Thapsigargin has been used as an endoplasmic reticulum (ER) stress inducer:
- to study its effect on cyclase-associated protein 2 (CAP2) expression in liver cancer cells
- in the cell viability experiment using ARPE -19 cells (human retinal pigment epithelial cells)
- to study its effect on lipocalin 2 (LCN2) glycosylation in primary hepatocytes
- to study the consequences of calcium depletion in the endoplasmic reticulum (ER) of cells
- to study its effect on tissue inhibitor of metalloproteinases-1 (TIMP-1) mRNA expression in rat Sertoli cells
Biochem/physiol Actions
Thapsigargin is a potent, cell-permeable, IP3-independent intracellular calcium release. It blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It also induces apoptosis by disrupting intracellular free Ca2+ levels and is incorporated into chemotherapeutic prodrug formulations.
- UPC:
- 12352200
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- T9033-.5MG
- CAS:
- 67526-95-8
