Thiomyristoyl (C09-1074-796)

InformationThiomyristoyl Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.TargetsSIRT2 (Cell-free assay) 28 nMIn vitroThiomyristoyl(TM) is a highly selective SIRT2 inhibitor. It cannot efficiently inhibit SIRT3, SIRT5, SIRT6, or SIRT7. it shows great inhibition of cell viability and its cytotoxicity is relatively selective toward cancer cells. TM decreases c-Myc oncoprotein level in cancer cells, the ability of TM to decrease c-Myc abundance in different cell lines correlates with the sensitivity of the cell lines to TM.In vivoThe anticancer effect of TM correlates with its ability to decrease c-Myc level. TM has limited effects on non-cancerous cells and tumor-free mice.Cell Research(from reference)Cell lines：breast cancer cell lines MCF-7 Concentrations：1, 5, 10, 25, 50 μM Incubation Time：6 h. Specification: 10mM in DMSO Molecular Formula: C34H51N3O3S Molecular Weight: 581.85 PubChem CID: 126843233 Isomeric SMILES: CCCCCCCCCCCCCC(=S)NCCCC[C@@H](C(=O)NC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2