Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties. Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1A protein synthesis-inhibiting antibiotic. Specification: 98%,from Streptomyces laurentii MDL Number: MFCD00135828 Molecular Formula: C72H85N19O18S5 Molecular Weight: 1664.89 EC Number: 215-734-9 PubChem CID: 16220061 Isomeric SMILES: CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)/C(=C/C)/NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/T102394-SCI_2ddb6e30691f7c16791e872bd9771562.pdf
- UPC:
- 12352200
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 1.02 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- T102394-1g
- CAS:
- 1393-48-2
- Product Size:
- 1g
- Hazard Statement Codes:
- H302
