Thomas Scientific

9&beta-hydroxy stereoisomer of PGF2&alpha much less active than PGF2&alpha in antifertility and bronchoconstrictor activities exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of

A potential metabolite of 8-iso PGF2&beta via the 15-hydroxy PGDH pathway.

8-iso-17-phenyl PGF2&beta is an isomer of bimatoprost (free acid) that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of 8-iso-17-phenyl PGF2&beta.

16,16-dimethyl PGF2&beta is a metabolically stable analog of PGF2&beta. It prevents bronchospasm in asthmatics but is less potent than PGE2.

A 9&beta-hydroxy isomer of 5-trans PGF2&alpha.

8-iso PGF2&beta is an isomer of PGF2&alpha with a non-enzymatic, non-cyclooxygenase origin. It is one of 64 possible isomers of PGF2&alpha which can be produced by free radical peroxidation of arachidonic acid.

An isomer of Vitamin E that has less potent antioxidant properties than &alpha-tocotrienol.

PGF1&beta is the C-9 epimer of PGF1&alpha. It was shown to enhance respiratory rate in experimental animals when administered intravenously.

A synthetic analog of PGF2&beta.

6&beta-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6&beta-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function.

A mycotoxin that inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis.

11-deoxy PGF1&beta is a synthetic analog of PGF1&beta. In contrast to PGF2&alpha and PGF1&alpha, 11-deoxy PGF1&beta exhibits vasodepressor and bronchodilator activities in guinea pigs at a dose of 500 &microg/kg.