Thomas Scientific

A cell-permeable, competitive, and irreversible inhibitor of all caspases, inhibiting cleavage of PARP and preventing apoptosis when used at 10-50 &microM blocks caspase-mediated apoptosis in vivo effectively prevents caspase action in

The ethyl ester analog of ochratoxin A.

The predominant female-specific mating pheromone of the fruit fly D. melanogaster that elicits wing vibrations in male D. melanogaster flies at amounts above 100 ng.

Source: 50 &microg of a complex of full length recombinant C-terminal His-tagged HDAC3 and recombinant N-terminal GST-tagged NCOR2 amino acids 395-489, co-expressed in baculovirus expression system Mr: 49.7 kDa (HDAC3) 37.

A naturally occurring caffeoyl conjugate with antioxidant and antiradical properties demonstrates neuroprotective effects (EC₅₀s = 0.9-3.7 &microM) in several in vitro models of neuronal death.

A hydroxylated metabolite of estrone as well as an interconversion product with estriol formed by CYP1A1, CYP3A5, CYP3A4, and CYP3A7 binds covalently and persistently activates estrogen receptors increases cell proliferation and does not suppress

A potent inhibitor of PI3K with selectivity for the g isoform inhibits human recombinant PI3Kg, a, d, with IC50 values of 30, 940, 20,000, and 20,000 nM, respectively.

A small molecule inhibitor of JAK2 (IC₅₀ = 6 nM) and the related kinases FLT3 (IC₅₀ = 25 nM) and RET (IC₅₀ = 17 nM) with significantly less potent activity against JAK3 (IC₅₀ = 169 nM) inhibits the growth

20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This &omega-oxidation conversion can take place using purified

An isomer of iloprost that potently inhibits platelet aggregation with an IC 50 value of 3.5 nM.

A potent inhibitor of PKC&beta (IC50 = 6 nM), with modest selectivity over PKC&alpha, &gamma, and &epsilon (IC50 = 39, 83, and 110 nM, respectively) at 3 &microM, also inhibits signaling through the Akt pathway suppresses angiogenesis,

A natural indole alkaloid with demonstrated beneficial effects in cancer, obesity, inflammation, and many other conditions an AhR antagonist (Ki = 28 nM), activator of TRPV1 (EC₅₀ = 45 nM), and inhibitor of signaling through NF-&kappaB.