Thomas Scientific

A 2-thiazolylhydrazone derivative that, at 10 &microM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria inhibits NAT10.

An ATP-competitive, pan-Akt kinase inhibitor (IC₅₀s = 2, 13, and 9 nM for Akt1, 2, and 3, respectively) that inhibits proliferation and induces apoptosis in various human tumor cells in vitro and in xenografts in immunocompromised mice.

A bioactive lipid produced by the sequential metabolism of anandamide by COX enzymes and PGD synthase inactive against recombinant prostanoid receptors, including DP increases the frequency of miniature inhibitory postsynaptic currents in

An ecdysteroid that drives molting in insects binds the heterodimeric ecdysone receptor with nanomolar affinity.

A racemic mixture of the lactone form of the free acid, 8,12-iso- iPF2&alpha-VI the free acid is the most abundant F2-iP2 regioisomer measured in the urine of rats treated to induce lipid peroxidation used as a biomarker for oxidative stress.

A potent inhibitor of I&kappaB kinases (IKKs), displaying IC₅₀values of 200, 40, and 70 nM for IKK&alpha, IKK&beta, and IKK complex, respectively, in cell-free assays effective in cells and in animals.

A form of biotin with a terminal azide group is used to add biotin to other molecules that bear either an alkyne group, through click chemistry, or a phosphine group, using Staudinger ligation.

A naturally occuring terpenoid that potently inhibits MAGL (IC₅₀ = 93 nM) at 1 &microM, significantly inhibits endogenous MAGL in isolated rat neurons.

A selective, potent, and cell-permeable inhibitor of mTOR (IC₅₀ = 4.3 nM) which blocks signaling through both mTORC1 and mTORC2 induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines and

A selective and competitive inhibitor of NAD+-dependent type-I 15-PGDH (IC₅₀ = 26.4 nM Ki = 5 nM).

A pan-CDK inhibitor (IC₅₀s = 3, 1, 1, and 4 nM for CDK1, CDK2, CDK5, and CDK9, respectively) that inhibits DNA synthesis in A2780 ovarian cancer cells (IC₅₀ = 4 nM) 5 mg/kg prevents tumor growth by 50% in an A2780 ovarian

Selective inhibitor of IDH1 R132H and R132C mutants in vitro (IC₅₀s = 0.07 and 0.