Thomas Scientific

A tumor vascular disrupting agent, inducing apoptosis in tumor vascular endothelium resulting in necrosis at the tumor core potently activates the STING/TBK1/IRF3 signaling pathway in mouse leukocytes, inducing type-I-IFN production inhibits

An NSAID that reduces edema in certain types of acute inflammation in animal models a poor inhibitor of prostaglandin synthesis, but, like other NSAIDs, it inhibits OAT1 (Ki = 32 &microM).

A cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC₅₀ = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay.

A nonpeptide renin inhibitor (IC₅₀ = 0.6 nM) that selectively binds to the S3 sub-pocket of renin, preventing the conversion of angiotensinogen to angiotensin I, thereby blocking eventual conversion to angiotensin II reduces blood

SEAP is commonly used as a reporter of gene expression. Compared to other conventional intracellular reporters such as CAT and firefly luciferase, SEAP has the advantage of being secreted from transfected cells into the culture medium.

15(R)-HETE is produced when aspirin-inhibited COX-2 is incubated with arachidonic acid. The clinical significance of 15(R)-HETE and its potential downstream metabolites is the subject of current investigations.

The predominant LO product of arachidonic acid formed in mammalian platelets enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 &microM.

A proinflammatory monohydroxy oxidation product of arachidonic acid formed by 12(R)-LO.

An internal standard for the quantification of tetranor PGEM by GC- or LC-MS.

A BTK inhibitor.

A photostable synthetic analog of ATRA that induces differentiation in human pluripotent embryonic stem cells when used within the range of 100 nM-10 &microM.

A potent inhibitor of the Wnt response, blocking a cell-based Wnt/&beta-catenin pathway reporter response (IC₅₀= 180 nM) inhibits Wnt-induced accumulation of &beta-catenin, leading to proteasomal degradation of this protein.