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THZ1 Hydrochloride (C09-1183-607)

Aladdin

Catalog No.
C09-1183-607
Manufacturer No.
T658911-5mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $169.89
List Price: $188.77

THZ1 Hydrochloride is a selective and potent covalent CDK7 inhibitor with an IC 50 of 3.2 nM. THZ1 Hydrochloride also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression.Appearance:SolidIC50& Target:CDK7|3.2 nM

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THZ1 Hydrochloride is a selective and potent covalent CDK7 inhibitor with an IC 50 of 3.2 nM. THZ1 Hydrochloride also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression.Appearance:SolidIC50& Target:CDK7|3.2 nM (IC|50|)|CDK12|CDK13In Vitro:THZ1 inhibits Jurkat cell and Loucy cell with IC 50 of 50 nM, and 0.55 nM, respectively. THZ1 demonstrates time-dependent inhibition of CDK7 in vitro and covalent binding of intracellular CDK7. THZ1 (9, 27, 83, 250, 750, and 2500 nM) inhibits CDK12 but atIn Vivo:THZ1 (10mg/kg) demonstrates potent killing of primary chronic lymphocytic leukemia (CLL) cells and anti-proliferative activity against primary TALL cells and in vivo against a human T-ALL xenograft. THZ1 (10mg/kg, i.v.) inhibits tumor growth in a mBiological Activity:THZ1 Hydrochloride is a selective and potent covalent CDK7 inhibitor with an IC 50 of 3.2 nM. THZ1 Hydrochloride also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression . Specifications and Purity: 98%. Molecular Formula: C31H29Cl2N7O2. Molecular Weight: 602.51.
UPC:
12352107
Condition:
New
Availability:
8-12 weeks
Weight:
1.09 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
T658911-5mg
Product Size:
5mg


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