General description
Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications.
The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.
Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.
Application
Gelatin methacrylate based bioinks have been used in the following bioprinting applications:
- osteogenic,
- chondrogenic ,
- hepatic ,
- adipogenic ,
- vasculogenic ,
- epithelial ,
- endothelial ,
- cardiac valve ,
- skin ,
- tumors
Features and Benefits
- Ready-to-use formulation optimized for high printing fidelity and cell viability, eliminating the lengthy bioink formulation development process
- Step-by-step protocols developed and tested by MilliporeSigma 3D Bioprinting Scientists, no prior 3D bioprinting experience neede
- Suitable for different extrusion-based 3D bioprinter model
- Methacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio.
Legal Information
TISSUEFAB is a registered trademark of Sigma-Aldrich Co. LLC
Quality Level: 100. sterility: 0.2 μ. m filtered. form: viscous liquid (to gel). size: 10 . mL . impurities: ≤. 5 . CFU/gBioburden
(Fungal), ≤. 5 . CFU/g Bioburden (Aerobic), ≤. 50 . EU/mL Endotoxin. color: pale yellow to colorless. pH: 6.5-7.5. viscosity: 2-20 . cP. application(s): 3D bioprinting. storage temp.: 2-8°C. Storage Class Code: 10 - Combustible liquids. WGK: WGK 3.- UPC:
- 41115711
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 925217-10ML