General description
An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.
An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 5 µM as TNF-α antagonist
Warning
Toxicity: Standard Handling (A)
Sequence
H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)
Other Notes
Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.
Legal Information
Sold under license of U.S. Patent 6,265,535.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 1226.38. Empirical Formula: C58H71N11O15S2. Quality Level: 100. Assay: ≥. 95% (HPLC). form: lyophilized. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, desiccated (hygroscopic). solubility: water: 1 . mg/mL, 5% acetic acid: 5 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51171967
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 654255-1MG
