General description
TOTU is an excellent alternative to HOBt-based coupling reagents such as HBTU and TBTU. It has high reactivity and is likely to have low allergenicity and low explosivity. The by-products of using this coupling reagent are water-soluble, making it an ideal choice for solution phase coupling reactions.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] G. Breipohl & W. Koenig, US patent 5166394.
Analysis Note
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): conforms
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clear soluble
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51442724
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 8510880100