Rat anti Mouse Transferrin Receptor/CD71 Antibody, Monoclonal (8D3), could be used for Flow, in vivo depletion of CD71+ cells, ICC, IF, IHC, WB and so on.Application:Flow: Use at an assay dependent concentration.in vivo depletion of CD71+ cells: Use at an assay dependent concentration.ICC/IF: Use at an assay dependent concentration.IHC: Use at an assay dependent concentration.WB: Use at an assay dependent concentration.Protein FunctionCellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
Specification: ExactAb™, Validated, Carrier Free, Azide Free, ≥95%(SDS-PAGE), Lot by Lot
Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/AB132256-SCI_733bdd77aebccd2f58aca44145a482ac.pdf
- UPC:
- 51131510
- Condition:
- New
- Availability:
- 5-10 days
- Weight:
- 0.07 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Ab132256-10μg
- Product Size:
- 10μg
